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Heterogeneity of the tumor immune microenvironment and clinical interventions
《医学前沿(英文)》 2023年 第17卷 第4期 页码 617-648 doi: 10.1007/s11684-023-1015-9
Zhaoshi Bao, Yongzhi Wang, Qiangwei Wang, Shengyu Fang, Xia Shan, Jiguang Wang, Tao Jiang
《医学前沿(英文)》 2021年 第15卷 第4期 页码 551-561 doi: 10.1007/s11684-020-0760-2
关键词: glioma evolution mechanism strategies tumor heterogeneity secondary glioma
Heterogeneity of chronic obstructive pulmonary disease: from phenotype to genotype
null
《医学前沿(英文)》 2013年 第7卷 第4期 页码 425-432 doi: 10.1007/s11684-013-0295-x
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality throughout the world and is mainly characterized by persistent airflow limitation. Given that multiple systems other than the lung can be impaired in COPD patients, the traditional FEV1/FVC ratio shows many limitations in COPD diagnosis and assessment. Certain heterogeneities are found in terms of clinical manifestations, physiology, imaging findings, and inflammatory reactions in COPD patients; thus, phenotyping can provide effective information for the prognosis and treatment. However, phenotypes are often based on symptoms or pathophysiological impairments in late-stage COPD, and the role of phenotypes in COPD prevention and early diagnosis remains unclear. This shortcoming may be overcome by the potential genotypes defined by the heterogeneities in certain genes. This review briefly describes the heterogeneity of COPD, with focus on recent advances in the correlations between genotypes and phenotypes. The potential roles of these genotypes and phenotypes in the molecular mechanisms and management of COPD are also elucidated.
关键词: chronic obstructive pulmonary disease heterogeneity phenotype genotype prediction
Na Qin, Yuancheng Li, Cheng Wang, Meng Zhu, Juncheng Dai, Tongtong Hong, Demetrius Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Gary Goodman, Stig E. Bojesen, Maria Teresa Landi, Mattias Johansson, Angela Risch, H-Erich Wichmann, Heike Bickeboller, Gadi Rennert, Susanne Arnold, Paul Brennan, John K. Field, Sanjay Shete, Loic Le Marchand, Olle Melander, Hans Brunnstrom, Geoffrey Liu, Rayjean J. Hung, Angeline Andrew, Lambertus A. Kiemeney, Shan Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Penella Woll, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Victoria L. Stevens, Guangfu Jin, David C. Christiani, Zhibin Hu, Christopher I. Amos, Hongxia Ma, Hongbing Shen
《医学前沿(英文)》 2021年 第15卷 第2期 页码 275-291 doi: 10.1007/s11684-020-0779-4
关键词: lung cancer genome-wide association study function annotation immune homologous recombination repair deficiency genetic heterogeneity
Computational modeling of fracture in concrete: A review
Luthfi Muhammad Mauludin, Chahmi Oucif
《结构与土木工程前沿(英文)》 2020年 第14卷 第3期 页码 586-598 doi: 10.1007/s11709-020-0573-z
关键词: concrete fracture macroscopic micromechanical heterogeneity
Analysis of stress and failure in rock specimens with closed and open flaws on the surface
《结构与土木工程前沿(英文)》 2021年 第15卷 第5期 页码 1222-1237 doi: 10.1007/s11709-021-0773-1
关键词: surface flaw heterogeneity circular hole numerical modeling relative displacement
A multiscale material model for heterogeneous liquid droplets in solid soft composites
《结构与土木工程前沿(英文)》 2021年 第15卷 第5期 页码 1292-1299 doi: 10.1007/s11709-021-0771-3
关键词: liquid in solid soft composite computational modeling multiscale model heterogeneity
Heterogeneous influence of individuals’ behavior on mask efficacy in gathering environments
《工程管理前沿(英文)》 页码 550-562 doi: 10.1007/s42524-022-0193-5
关键词: COVID-19 masks behavioral heterogeneity asymptomatic infection
Machine learning modeling identifies hypertrophic cardiomyopathy subtypes with genetic signature
《医学前沿(英文)》 2023年 第17卷 第4期 页码 768-780 doi: 10.1007/s11684-023-0982-1
关键词: machine learning methods hypertrophic cardiomyopathy genetic risk
Interplay between diet and genetic susceptibility in obesity and related traits
Tiange Wang, Min Xu, Yufang Bi, Guang Ning
《医学前沿(英文)》 2018年 第12卷 第6期 页码 601-607 doi: 10.1007/s11684-018-0648-6
The incidence of obesity has been rapidly increasing, and this condition has become a major public health threat. A substantial shift in environmental factors and lifestyle, such as unhealthy diet, is among the major driving forces of the global obesity pandemic. Longitudinal studies and randomized intervention trials have shown that genetic susceptibility to obesity may interact with dietary factors in relation to the body mass index and risk of obesity. This review summarized data from recent longitudinal studies and intervention studies on variations and diets and discussed the challenges and future prospects related to this area and public health implications.
Optimal design of steel skeletal structures using the enhanced genetic algorithm methodology
Tugrul TALASLIOGLU
《结构与土木工程前沿(英文)》 2019年 第13卷 第4期 页码 863-889 doi: 10.1007/s11709-019-0523-9
关键词: design optimization genetic algorithm multiple populations neural network
Research progress on genetic improvement of
Chuanping YANG
《农业科学与工程前沿(英文)》 2017年 第4卷 第4期 页码 391-401 doi: 10.15302/J-FASE-2017183
关键词: Betula platyphylla genetic improvement molecular breeding seed orchard
Factors affecting the distribution of microplastics in soils of China
《环境科学与工程前沿(英文)》 2023年 第17卷 第9期 doi: 10.1007/s11783-023-1710-4
● Microplastic (MP) abundance in soil of China was highly heterogeneous.
关键词: Microplastic distribution Microplastic heterogeneity Effecting factors Agriculture Socio-economic factors
Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma
《医学前沿(英文)》 2023年 第17卷 第2期 页码 240-262 doi: 10.1007/s11684-022-0936-z
关键词: glioma progression molecular classification EM/PM subtyping intratumor heterogeneity
Genomics and genetic breeding in aquatic animals: progress and prospects
Wenteng XU, Songlin CHEN
《农业科学与工程前沿(英文)》 2017年 第4卷 第3期 页码 305-318 doi: 10.15302/J-FASE-2017154
标题 作者 时间 类型 操作
Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and
Zhaoshi Bao, Yongzhi Wang, Qiangwei Wang, Shengyu Fang, Xia Shan, Jiguang Wang, Tao Jiang
期刊论文
Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between
Na Qin, Yuancheng Li, Cheng Wang, Meng Zhu, Juncheng Dai, Tongtong Hong, Demetrius Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Gary Goodman, Stig E. Bojesen, Maria Teresa Landi, Mattias Johansson, Angela Risch, H-Erich Wichmann, Heike Bickeboller, Gadi Rennert, Susanne Arnold, Paul Brennan, John K. Field, Sanjay Shete, Loic Le Marchand, Olle Melander, Hans Brunnstrom, Geoffrey Liu, Rayjean J. Hung, Angeline Andrew, Lambertus A. Kiemeney, Shan Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Penella Woll, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Victoria L. Stevens, Guangfu Jin, David C. Christiani, Zhibin Hu, Christopher I. Amos, Hongxia Ma, Hongbing Shen
期刊论文
Computational modeling of fracture in concrete: A review
Luthfi Muhammad Mauludin, Chahmi Oucif
期刊论文
Machine learning modeling identifies hypertrophic cardiomyopathy subtypes with genetic signature
期刊论文
Interplay between diet and genetic susceptibility in obesity and related traits
Tiange Wang, Min Xu, Yufang Bi, Guang Ning
期刊论文
Optimal design of steel skeletal structures using the enhanced genetic algorithm methodology
Tugrul TALASLIOGLU
期刊论文